Ecg4me device is based on the “Health-Express” software module, which is widely used in medical practice for screening examinations and includes two analysis methods.

When choosing an ECG registration duration of 30 seconds, an examination will be carried out using the Cardiovisor technique, and when choosing a duration of 3 or 5 minutes, an extended examination will be carried out using the Cardiovisor technique and the Heart Rate Variability technique.

The Cardiovitor technique is a method for analyzing ECG microalternations, which selects 30-second sections from an ECG recording and for each section, an automatic analysis of low-amplitude oscillations of the ECG signal in successive heart contractions is carried out. This is fundamentally different from standard ECG contour analysis. Microalternations are sensitive indicators of the overall functioning of the physiological systems of the body involved in the mechanisms of cardiac regulation. The cardiovisor responds to changes in the ion balance in myocytes, shifts in sympathoadrenal activation and other metabolic changes, which, due to their small magnitude, do not appear in the morphology of the ECG or ultrasound of the heart. Similarly, the Cardiovisor reacts to the hidden dynamics of the compensatory reaction of the left ventricle, which makes it possible to timely identify the state of cardiac overload.

The characteristics of microalternations are represented by the integral Myocardium index and nine indicators detailing changes in the parts of the heart, as well as in the intervals of de- and repolarization. A map of averaged amplitudes of microalternations is formed in the form of a 3-dimensional color model of the heart (dispersion portrait of the heart).

Normally, the Myocardium index is within the range of 0-14%, the borderline state is 15-18%, a value of 19% and above is a deviation.

According to the results of testing on the ECG database DB-PTB of the Institute of Metrology of Germany, when dividing the norm-pathology groups, the sensitivity of the Myocardium index was 84% and the specificity was 73%.

Analysis of heart rate variability (HRV) is a standard, scientifically based methodology for prenosological diagnostics to obtain information about the degree of tension of regulatory systems, as a nonspecific response of the body to any adverse effects that require the mobilization of functional reserves.

The method for assessing HRV using a 3- or 5-minute ECG recording calculates time and frequency parameters, and also classifies the functional state of the body based on ideas about homeostasis and adaptation with the calculation of the Activity Index of Regulatory Systems (PARS).