Objective: ECG dispersion mapping (ECG-DM) is a novel technique that analyzes low amplitude ECG oscillations and reports them as the myocardial micro-alternation index (MMI). This study compared the ability of ECG-DM to predict in-hospital mortality with traditional risk factors such as age, vital signs and comorbid diagnoses, as well as three predictive scores: the Simple Clinical Score (SCS) – based on clinical and ECG findings, and two Medical Admission Risk System scores – one based on vital signs and laboratory data (MARS), and one only on aboratory data (LD). Methods: A convenient sample of 455 acutely ill medical patients (mean age 69.7±14.0 years) had their vital signs, mental and functional status recorded and a 12 lead ECG, routine laboratory investigations and ECG-DM performed immediately after admission to hospital. Each patient's in-hospital course and diagnoses at death or discharge were reviewed. Results: Of the vital signs only oxygen saturation and respiratory rate were statistically significant predictors of death. The continuous variables that predicted death the best were: MARS, SCS, LD, white cell count and MMI. The categorical variables that predicted in-hospital mortality with highest Chi-square were: a diagnosis of stroke, SCS N=12, LDN0.10, MARS N0.09 and MMI N36%.
Conclusion: ECG-DM may be a clinically useful predictor of in-hospital mortality. ECG-DM is inexpensive, only takes a few seconds to perform and requires no skill to interpret. © 2011 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

Abstract :
Objective— The HeartVueTM 6S System is a recently developed novel technology that may provide non-invasive assessment of myocardial ischaemia by analysing low amplitude oscillations of the conventional ECG signals (ECG dispersion mapping). The available data to validate this new technology is limited. Therefore we performed a prospective study to assess the HeartVueTM 6S System for the detection of myocardial ischaemia during coronary occlusion in patients undergoing percutaneous coronary intervention (PCI).
Methods— A total of 101 patients undergoing cardiac catheterization were prospectively enrolled. HeartVueTM 6S System ECG dispersion mapping was obtained at baseline, and during the first balloon inflation and at the end of the procedure if PCI was performed. Parameters provided by the HeartVueTM 6S System were analysed.
Results— Fifty patients who underwent PCI comprised the final study population. The mean age was 63.7 ± 10 years and 58% were men. In 58% of cases the indication was acute coronary syndrome. In 98% of patients, PCI was successful. There were significant differences in the G7+G9 values between the first inflation and the end of the procedure, which reflect changes in ventricular depolarization (P =0.02 by Wilcoxon signed rank test). Conclusions — The HeartVueTM 6S System may have potential for a non-invasive assessment of ischaemia in patients with suspected coronary artery disease. Larger studies are warranted to confirm these preliminary findings.

The article presents the results of studying electrophysiological changes in the myocardium of normal human subjects during 7-day dry immersion, and modification of the reaction to immersion by amlodipin and myostimulation. The dry immersion effects on the myocardium generally include a succession of electrophysiological shifts first in the ventricles and then in the left atrium due to, probably, blood pooling in the pulmonary vessels. Myostimulation and amlodipin affect the myocardium reaction visibly suggesting involvement of numerous components of the autonomous and central nervous systems. The positive effect of the pharmaceutical--alleviation of myocardium strain--is a result of amlodipin assistance to the coronary blood flow; however, it has a side-effect on orthostatic stability. The positive action of myostimulation is associated with unloading of the right heart and reflected in changed HD ECG parameters and growth of the "myocardium" index.

172patients with various cardiovascular diseases -87patients without coronary heart disease (CHD) and 85 patients without CHD.
Conclusions.
1. Evaluation of the sensitivity of CardioVisor-06s has shown that by authenticity and efficiency of obtaining information it is suitable for screening examinations to detect cardiac pathologies.
2. The device has adequate sensitivity and specificity indicators (79% and 63%) when used to detect CHD.
3. The device has resources for further highly sensitive control of dynamics of myocardial metabolic stste to evaluate the results of applied therary.

We studies 57 DM2 patients. For myocardial damage identification rest ECG with 12 leads, daily ECG monitoring by Holter, echocardiography were used. The fasting glycaemia, total cholesterol (Chl), Chl in LPHD, LPLD, TG, aterogenic coefficient were taking in account. For dispersed ECG mapping CardiovisorTM- Russian version of HeartVueTM(Heart View Ltd, USA) was used. A model of cardiac biogenerator was designed on the basis of the low amplitude dispersed ECG-signal characteristics. The integral index of myocardial changes (IIMC) in percent and the vector of fluctuation of dispersion (VFDD), including 11 different components, were analyzed.

The results: 1. All patients with DM2 were divided into 3 groups on the basic of IIMC significances: IIMC under 15% (I gr. 13 pts.), from 16 to 25% (II gr. 25 pts.), above 26% (III gr. 19 pts.)/ It was revealed a positive correlation between IIMC and TG level (r=0,79, p<0,05), IIMC and atherogenic coefficient (r=0,6, p<0,05); 2. 5 and 8 components of the VDDT of the low amplitude dispersion ECG were registered with a more higher frequency. A positive correlations between with 2, 5, 8 components and IIDM (r=o,88, p<0,001) was identified.

Conclusion: an information model of myocardial electromagnetic E-field raliation in moderate severity DM2 patients is characterized by the structural changes of 2, 5, and 8 components of VDDF of low amplitude ECG dispersions, that mirror the impaired phase of repolarization of the potentials action. The integral index of myocardial changes had a positive correlation with aterogenic biochemical parameters.